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Important factors that could cause actual results to differ materially from these expectations include, among other things, acceptance and demand for once-daily tramadol in particular regions, the impact of competitive products and pricing, regulatory matters including compliance with pharmaceutical regulations, availability of raw materials and finished products, the regulatory environment, the outcome of legal proceedings and other risks detailed from time to time in the Companys filings with the Securities and Exchange Commission and the Canadian Securities Administrators, as well as the Companys ability to anticipate and manage the risks associated with the foregoing.

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